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Nutrigenomics: Research projects

A Foundation for Evidence-Based Management of Nutrigenomics Expectations and ELSIs

 

With the introduction of genomic technologies and their application to nutritional sciences, the field of nutrigenomics is rapidly coming of age. Nutrigenomics allows the study of ‘variability questions’ in host-diet interactions and attendant contribution of genetic factors. Nutrigenomics information may be relevant for patients but also for healthy populations. However, this public health focus of nutrigenomics research, and day-to-day importance of food in people’s lives, may raise hitherto unexpected ethical-legal-social issues (ELSIs). Clinical and public health expectations on nutrigenomics are slowly developing which can exceed the threshold for biohype if not approached by the scientific community in an evidence-based manner.

For nutrigenomics research to maintain its present pace and momentum, investigators cannot neglect the significance of socio-ethical factors in the uptake of innovation and adoption of new health technologies in the clinic. Although there have been discussions about the future potential of applied nutrigenomics research and clinical services, little attention has been given to the specific ELSIs... Read more

Publications

Lafrenière, D., Hurlimann, T., Menuz, V., Godard, B. (2014) Evaluation of a cartoon-based knowledge dissemination intervention on scientific and ethical challenges raised by nutrigenomics/nutrigenetics research. Eval Program Plann. 46C: 103-114. doi: 10.1016/j.evalprogplan.2014.06.002. [Epub ahead of print]

Stenne R, Hurlimann T, Godard B. "Benefits Associated with Nutrigenomics Research and Their Reporting in the Scientific Literature: Reserchers' Perspectives." Accountability in Research 2013; 20(3); 167-83.

Hurlimann, T., Menuz, V., Graham, J., Robitaille, J., Vohl, M.C., and Godard, B. (2014) Risks of nutrigenomics and nutrigenetics? What the scientists say. Genes & Nutrition 9(1). Epub ahead of print: December 2013.

Lafrenière, D., Hurlimann, T., Menuz, V. and Godard, B. (2012) “Health Research: Ethics and the Use of Arts-Based Methods in Knowledge Translation Process” International Journal of Creative Arts in Interdisciplinary Practice 11(1).

Stenne, R., Hurlimann, T., Godard, B. (2012) Are Research Papers Reporting Results from Nutrigenetics Clinical Research a Potential Source of Biohype? Accountability in Research: Policies and Quality Assurance 19(5): 285-307.

Hurlimann, T., Stenne, R., Menuz, V. and Godard, B. (2011) "Inclusion and exclusion in nutrigenetics research: ethical & scientific challenges" Journal of Nutrigenetics and Nutrigenomics 4(6): 322-43

Godard, B., Hurlimann, T. (2009) "Nutrigenomics for Global Health: Ethical Challenges for Underserved Populations" Current Pharmacogenomics and Personalized Medicine 7(3): 205-14.

Hurlimann, T. (2009) "Les promesses de la nutrigénomique pour les pays en voie de développement: au-delà de l’exploitation commerciale et du battage médiatique" Online

Date: From 2008 to 2013
Research Team : Béatrice Godard,  Janice Graham,  Thierry Hurlimann,  Vincent Menuz,  Julie Robitaille,  Raphaëlle Stenne,  Marie-Claude Vohl
Funding: Canadian Institutes of Health Research (CIHR)
Contact: Béatrice Godard
Aligning Socio-Ethical Studies with '-Omics' Technology Applications: From Discovery Research to Personalized Health Interventions

 

Following the completion of the Human Genome Project in 2003, the availability of high throughput -omics technologies led to the emergence of the concept of 'personalized health interventions'. Among the most prominent -omics technologies that enable personalized health interventions is nutrigenomics, that aims to individualize nutrition based on individual genetic makeup. While nutrigenomics is expected to be implemented in personalized health interventions, there has yet to be produced a comprehensive inventory of associated ethical-legal-social issues (ELSIs). Nor has ethics research on personalized health interventions sufficiently taking into account the unique ELSIs introduced by different -omics technologies (such as nutrigenomics) and the bioscience application context. Nutrigenomics tests for routine clinical use are at an early stage of development while there are intensive nutrigenomics bioscience efforts in both preclinical and clinical research domains. Nutrigenomics has broad public health significance since it focuses on both patients and healthy populations as well as the discernment of nuanced differences in pre-disease states in... Read more

Publications

Stenne R, Hurlimann T, Godard B. "Benefits Associated with Nutrigenomics Research and Their Reporting in the Scientific Literature: Reserchers' Perspectives." Accountability in Research 2013; 20(3); 167-83.

Hurlimann, T., Menuz, V., Graham, J., Robitaille, J., Vohl, M.C., and Godard, B. (2014) Risks of nutrigenomics and nutrigenetics? What the scientists say. Genes & Nutrition 9(1). Epub ahead of print: December 2013.

Stenne, R., Hurlimann, T., Godard, B. (2012) Are Research Papers Reporting Results from Nutrigenetics Clinical Research a Potential Source of Biohype? Accountability in Research: Policies and Quality Assurance 19(5): 285-307.

Hurlimann, T., Stenne, R., Menuz, V. and Godard, B. (2011) "Inclusion and exclusion in nutrigenetics research: ethical & scientific challenges" Journal of Nutrigenetics and Nutrigenomics 4(6): 322-43

Godard, B., Hurlimann, T. (2009) "Nutrigenomics for Global Health: Ethical Challenges for Underserved Populations" Current Pharmacogenomics and Personalized Medicine 7(3): 205-14.

Hurlimann, T. (2009) "Les promesses de la nutrigénomique pour les pays en voie de développement: au-delà de l’exploitation commerciale et du battage médiatique" Online

Date: From 2008 to 2013
Research Team : Béatrice Godard,  Janice Graham,  Thierry Hurlimann,  Vincent Menuz,  Julie Robitaille,  Raphaëlle Stenne,  Marie-Claude Vohl
Funding: Fonds de la recherche en santé du Québec (FRSQ)
Contact: Béatrice Godard